ANTI CANCER ACTIVITY OF ZnO NANOPARTICLES on MCF7 (BREAST CANCER CELL) AND A549 (LUNG CANCER CELL)

ZnO nanoparticles have been proved to be promising in cancer treatment, including the tumor cells destruction with minimal damage to the healthy cells. In the present study highly pure ZnO nano particles with a narrow size distribution of 16-19 nm were prepared by the simple DMC (Dry Mechano-Chemical) method in the lab. The anticancer activity on MCF7 (Breast cancer cell) and A549 (Lung Cancer cell) were determined by the MTT (Methylthiazolydiphenyl-tetrazolium bromide) assay. A549 and MCF-7 cells were exposed to ZnO-NPs and it exhibited 50% reduction at a very low concentration 31.2 μg/ml. Thus, the reduction in cell viability with NPs induces cytotoxicity in cancerous cells. There is a size dependent effectiveness of ZnO nanoparticles in the removal of cancer cells and also a positive correlation with reduced toxicity.